Article

Projet
Biocapteurs et nano-assemblages d’acide nucléique  
Eric PEYRINLuc CHOISNARDCorinne RAVELETValérie GUIEUMickaël HENRY,   
Titre
Colorimetric nanosensor based on a selective target-responsive aptamer kissing complex  
Auteurs
E. Goux, E. Dausse, V. Guieu, L. Azéma, G. Durand, M. Henry, L. Choisnard, J-J. Toulmé, C. Ravelet, E. Peyrin
Edition
Nanoscale, 2017, 9, 4048 - 4052.
Année
2017
Résumé
Herein, we report a novel approach for the design of a colorimetric aptasensor based on functionalized gold nanoparticle probes. The approach relies on the conjugation of nanoparticles by two functional DNA and RNA hairpins that engage specific kissing (loop-loop) interactions in response to the addition of a small analyte ligand, leading to the particle aggregation and then red-to-purple colour change of the colloidal solution