Article

Projet
Chimie des produits naturels  
Ahcène BOUMENDJELRomain HAUDECOEUR,   
Titre
Human Tyrosinase and related proteins, are they new targets to fight melanoma?  
Auteurs
E. Buitrago, R. Hardre, R. Haudecoeur, H. Jamet, C. Belle, A. Boumedjel, M. Reglier
Edition
Curr. Top. Med. Chem. 2016, 3033-3047.
Année
2016
Résumé
Among the human copper-containing monooxygenases, Tyrosinase (Ty) is a very important enzyme that is involved in the determinant step of the biosynthetic pathway of melanin pigment. In this pathway, Ty catalyzes the tyrosine monooxygenation into DOPA-quinone, which is the precursor of the skin pigment melanin. Ty inhibitors/activators are a well-established approach for controlling in vivo melanin production, so their development has a huge economical and industrial impact. Moreover, recent publications highlight that targeting tyrosinase with inhibitors/activators to treat melanogenesis disorders is one of many possible approaches, due to the complex biochemical reaction involved in the melanin synthesis.